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Title   Chlorophyll Derivatives ( CpD ) 의 백서 복수암에 대한 Photodynamic Therapy 효과 ( The Effective Use Chlorophyll Derivatives ( CpD ) in Photodynamic Therapy of Ascites Tumors in Mice )
Publicationinfo   1989 Jan; 021(01): 1-7.
Key_word   Photodynamic therapy, photosensitizer, chlorophyll derivatives (CpD), ascites tumor
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Abstract   A murine ascites tumor was treated with intraperitoneal chlorophyll derivatives (CpD), which were developed as a new photosensitizer in Korea, and light of an appropriate wavelength (670nm). Photodynamic therapy (PDT) was given 3 times at 24h, 48h, and 72h after injection of CpD intraperitoneally. When the PDT was started at 1 week after inoculation of S-180 tumor cells, 80% of the complete remission(clinical) ratewas obtained. When the PDT was started at the 14th day or at the 21st day, the complete remission (clinical) rate was 30% or 0% respectively. This suggested that the lesser the tumor burden was, the higher the complete remission rate was. Our results illustrate the effective use of CpD in photodynamic therapy for the treatment of ascites tumors and reveal the possibility for photodynamic therapy in human ascites tumors.
저 자   박용준(Young Joon Park),이원영(Won Young Lee),한보섭(Bo Sup Hahn),한만정(Man Jeong Hahn),노재경(Jae Kyung Roh),김병수(Byung Soo Kim)